Acute Kidney Injury (AKI) and Acute Kidney Disease (AKD) in Patients With Coronavirus Disease 2019 (COVID-19)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 900
- 试验地点
- 1
- 主要终点
- Incidence of AKI
研究概览
简要总结
Acute kidney injury (AKI) has been identified as an independent risk factor for in-hospital mortality. The present study aims to investigate the incidence of AKI and renal recovery of inpatients diagnosed with COVID-19.
详细描述
Beginning in December 2019, a novel coronavirus, designated as severe acute respiratory distress coronavirus 2 (SARS-CoV-2), has caused an international outbreak of respiratory illness termed coronavirus disease 2019 (COVID-19). Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, some patients show severe kidney abnormalities. Acute kidney injury (AKI) has been identified as an independent risk factor for in-hospital mortality. The present study aims to investigate the incidence of AKI and renal recovery of inpatients diagnosed with COVID-19.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with COVID-19 diagnosed by World Health Organisation (WHO) criteria
排除标准
- •Patients aged less than 18 years
- •Patients with stage 4 chronic kidney disease (baseline estimated glomerular filtration rate <30 ml/min/1.73 m2)
- •Patients receiving maintenance dialysis
- •Recipients of solid-organ transplantation
结局指标
主要结局
Incidence of AKI
时间窗: 30 days post-hospital admission
Serial assessment of serum creatinine and urine output
Cystatin C as indicator of mortality
时间窗: 30 days post-hospital admission
All-cause mortality
Cystatin C as indicator of renal disease
时间窗: 30 days post-hospital admission
AKI and acute kidney disease (AKD)
Cystatin C as indicator of disease severity
时间窗: 30 days post-hospital admission
Rate of intensive care unit admission
Cystatin C as indicator of respiratory illness
时间窗: 30 days post-hospital admission
Ventilator-free days
次要结局
未报告次要终点