The Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Evidence of clinically cognitive function decline ：Apolipoprotein J（ApoJ）
研究概览
简要总结
According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups. The different combinations of propofol and sevoflurane were used in the four groups: 1 day before surgery, after patients become wide-awake, and 3 days, 7 days, and 3 months after surgery, the patient's cognitive function was evaluated using a professional cognitive scale and other indicators. Finally, statistical analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Elective orthopaedic surgery
- •American Society of Anesthesiologists physical status: II
排除标准
- •Neurological diseases that may affect cognitive function (e.g., subdural hematoma)
- •Hypothyroidism
- •Alcoholic dementia
研究组 & 干预措施
Propofol
administrated Target Controlled Infusion （TCI）of propofol （Cp 2.0~2.5μg/ml ）for maintaining
干预措施: Propofol (Drug)
1.2 μg/ml Propofol
administrated Target Controlled Infusion （TCI）of propofol （Cp 1.2 μg/ml ）combined with appropriate sevoflurane for maintaining
干预措施: Propofol (Drug)
1.2 μg/ml Propofol
administrated Target Controlled Infusion （TCI）of propofol （Cp 1.2 μg/ml ）combined with appropriate sevoflurane for maintaining
干预措施: Sevoflurane (Drug)
0.6 μg/ml Propofol
administrated Target Controlled Infusion （TCI）of propofol （Cp 0.6 μg/ml ）combined with appropriate sevoflurane for maintaining
干预措施: Propofol (Drug)
0.6 μg/ml Propofol
administrated Target Controlled Infusion （TCI）of propofol （Cp 0.6 μg/ml ）combined with appropriate sevoflurane for maintaining
干预措施: Sevoflurane (Drug)
Sevoflurane
administrated 1.3 minimum alveolar concentration（MAC ） sevoflurane for maintaining
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Evidence of clinically cognitive function decline ：Apolipoprotein J（ApoJ）
时间窗: Change from Baseline Apolipoprotein J at 7 days
Measurement by ELISA kit
次要结局
- Mini mental Examination(MMSE)(preoperative 24 hours ， 7 days post surgery)
- Montreal Cognitive Assessment（MoCA)(preoperative 24 hours ，7 days post surgery)
- Evidence of clinically cognitive function decline ：Soluble CD14（sCD14）(Change from Baseline Soluble CD14 at 7 days)