IRCT20110530006652N2已完成3 期
The effect of Oleoylethanolamide supplementation on peroxisome proliferator-activated receptor alpha gene expression, pyroptosis pathway genes (TLR4, TRIF, MYD88, NLRP3, Caspase 1, Caspase 8, IL1ß and IL18), lipopolysaccharide binding protein, metabolic parameters, and anthropometric indices in obese patients with non-alcoholic fatty liver disease
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 74
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20 years 至 50 years（—）
- 性别
- All
入选标准
- •Age between 20 to 50 years old
- •Body mass index (BMI) of 30 to 40 Kg/m2
- •Diagnosis of non-alcoholic fatty liver disease by a radiologist based on ultrasonography
排除标准
- •Regular use of non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics and corticosteroids
- •Use of hormonal drugs, hepatotoxic drugs (such as Phenytoin, Amiodarone, Levothyroxine, Tamoxifene and Lithium), anti-hypertensive drugs, weight loss and lipid lowering drugs
- •Use of prebiotic and probiotic supplements, vitamins, minerals, antioxidants, and omega 3 supplements
- •Diagnosed pathological conditions affecting the liver such as liver transplantation, acute or chronic hepatic impairment, viral hepatitis, cystic fibrosis, Haemochromatosis, Wilson's disease, Alpha-1 antitrypsin deficiency, and acute systemic disease
- •Diagnosed thyroid disorders
- •Diagnosed kidney diseases
- •Diagnosed gastrointestinal diseases (e.g. Celiac disease)
- •Diagnosed diabetes
- •Diagnosed heart failure
- •Diagnosed autoimmune diseases
- •Diagnosed malignancies
- •Diagnosed severe psychological disorders
- •Pregnancy and lactation
研究者
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