Effect of heat-inactivated Lactobacillus sp. on sleep, stress and gastrointestinal health in adults with insomnia and elevated stress levels: a randomised, controlled trial

niversity of Otago0 个研究点目标入组 90 人开始时间: 2023年4月13日最近更新: 2023年6月21日

适应症

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•To be eligible to participate, people must meet both 1 and 2 of the following inclusion criteria:
•1)Experiencing sleep disturbances (difficulty getting to sleep, and/or staying asleep and/or waking too early over the last three months).
•2)Experiencing elevated stress

•- having a current clinical diagnosis of a sleep disorder (such as sleep apnea, sleep movement disorder or narcolepsy) or have had a recent major depressive episode or clincal diagnosis of schizophrenia, manic-depression or bipolar disorder
•- taking prescribed medications for a sleep disorder or psychiatric disorder
•- taken antibiotics wihtin the month before starting the trial
•- medical history of severe gastrointestinal disorder (such as inflammatory bowel disease, coeliac disease) or clinically significant medical condition
•- taking prescribed medications such as opioid pain killers, non-steroidal anti-inflammatory drugs
•- are pregnant or lactating
•- are current smokers
•- have excessive alcohol intake (>21 standard drinks a week)
•- unwilling to avoid probiotic or prebiotic supplements, or foods/beverages containing high levels of live lactic acid bacteria

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