The Correlation Between the Cotinine Levels in Urine and Postoperative Acute and Chronic Pain in Open Abdominal Hysterectomy Patients
试验速览
- 阶段
- 4 期
- 入组人数
- 158
- 试验地点
- 2
- 主要终点
- Chronic pain: VAS score
研究概览
简要总结
It is known that there is an association between smoking and acute/chronic pain. But it is so difficult to assess this relation with asking questions to the patients in the preoperative period. Because of that we want to measure the levels of the cotinine in the urine and later assess the correlation with acute and chronic pain in hysterectomy patients.
详细描述
It is well-known that smoking is very common in the public. The chronic pain after hysterectomy is 20-40%. The open abdominal hysterectomy ratio is 75% of all hysterectomy operations in our country. We know that the reasons of postoperative acute and chronic pain is multifactorial. One of them is smoking which affects the postoperative pain. The best way of measuring the level of cotinine is assesing the urine of the patient. We collect the first urine after induction.
In this study, we aimed to investigate the correlation between the levels of urine cotinine and the acute and chronic postoperative pain in hysterectomy patents.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Open abdominal hysterectomy patients
排除标准
- •Chronic pain
- •Chronic pain killer users
- •Axis I psychiatric disease
- •Liver disease
- •Renal disease
- •Drug allergy
结局指标
主要结局
Chronic pain: VAS score
时间窗: Postoperative 3 months
3rd month pain after hysterectomy (VAS score)
次要结局
- Acute pain: VAS score(Postoperative 48 hours)
研究者
Onur Koyuncu
Assoc.Prof.MD
Mustafa Kemal University