Heading in Football: Impact on Neural Blood Biomarkers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 335
- 试验地点
- 1
- 主要终点
- Concentration of serum neurofilament light protein
研究概览
简要总结
The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage. The main questions this study aims to answer are:
- Does participation in a football match lead to a change in biomarkers that reflect microscopic neural damage?
- Is the dose of exposure during a football match related to the magnitude of change in biomarkers that reflect microscopic neural damage?
Participants will participate in a regular football match and provide blood samples before and right after the football match. The football match will be recorded on video to count the number of headers of all participants.
详细描述
The objective of this prospective observational study is to determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting. Healthy amateur football players will be recruited to participate in the study. Participants will be invited to play a regular football match for investigation purposes. They will provide a blood sample within one hour before the start of the match and a second blood sample within one hour after the match. Participants will be asked to provide a third blood sample within 48 hours after participation, but this is not obligatory. The football match will be recorded on video to determine the number of head impacts of all participants. Furthermore, participants will wear heart rate sensors and local positioning sensors to determine the internal and external training load and account for the possible confounding effects of exercise on neural blood biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Member of the KNVB;
- •18 years or older;
- •Self-reported fitness to play 70-90 minutes (absence of injury).
排除标准
- •Sustained a head injury in the last year;
- •History or current neurological condition;
- •Regular participation in other contact sports (e.g. rugby, American football, ice hockey, fighting sports);
- •(Former) military personnel with a history of fighting/blast exposure
结局指标
主要结局
Concentration of serum neurofilament light protein
时间窗: T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match)
The difference in serum neurofilament light protein between pre-match samples and post-match samples.
次要结局
- Concentration of serum p-tau protein(T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match))
- Concentration of serum Glial Fibrillary Acidic Protein(T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match))
- Concentration of serum beta-synuclein(T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match))
- Concentration of serum Neuron Specific Enolase protein(T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match))
- Concentration of serum S100B protein(T0 (<1hour pre-match), T1 (<1hour post-match), T2 (<48hour post-match))
研究者
Prof. dr. Jaap Oosterlaan
Director Follow me programme
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)