Plasma Neurofilament Light and Its Relationship With Omega-3 Status and Soccer Heading in Women Soccer Players

Completed

• Conditions: Brain Trauma
• Interventions: Other: Plasma Neurofilament Light (NF-L); Other: Omega-3 Index; Other: HeadCount Questionnaire

• Registration Number: NCT05457023
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The purpose of this study is to (1) assess how a competitive season of purposeful gameplay soccer heading in collegiate women soccer players is related to a blood biomarker for sports-related brain injury, plasma neurofilament light (NF-L), and (2) examine how a player's omega-3 status is related to plasma NF-L concentration changes during and after a competitive season of gameplay soccer heading.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-07-07
• Study First Submitted QC: 2022-07-11
• Study First Posted: 2022-07-13
• Study Start: 2022-07-28
• Status Verified: 2023-11
• Primary Completion: 2023-11-09
• Study Completion: 2023-11-09
• Last Update Submitted: 2023-11-09
• Last Update Posted: 2023-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 27

Inclusion Criteria

• At least 18 years of age.
• Active player on the university's current team roster for the upcoming competitive season.
• Is eligible to participate in games and is not redshirting.

Exclusion Criteria

• Is recovering from a Physician diagnosed concussion.
• Is recovering from another injury prohibiting the study participant from participating in all sport-related activities.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Collegiate Women Soccer Players	Omega-3 Index	National Collegiate Athletic Association (NCAA) players.
Collegiate Women Soccer Players	HeadCount Questionnaire	National Collegiate Athletic Association (NCAA) players.
Collegiate Women Soccer Players	Plasma Neurofilament Light (NF-L)	National Collegiate Athletic Association (NCAA) players.

Primary Outcome Measures

Name	Time	Method
Change in plasma neurofilament light concentrations from baseline, during, and after a competitive season.	Baseline, 1 Months, 2 Months, 3 Months, 6 Months	Plasma neurofilament light (pg/mL) is a biomarker of axonal brain injury following sports-related head impacts.
Change in purposeful soccer heading frequencies from baseline, during, and after a competitive season.	Baseline, 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks, 14 weeks	HeadCount is a web-based, structured, self-administered questionnaire to assess longer-term heading frequencies (#) during competitive play and is administered bi-weekly.
Change in Omega-3 status from baseline, during, and after a competitive season.	Baseline, 1 Months, 2 Months, 3 Months, 6 Months	Omega-3 Index (%) is the omega-3 fatty acid content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) within membrane of red blood cell. It is expressed as EPA+DHA as a percent of total identified fatty acids.

Trial Locations

Locations (2)

University of Missouri Kansas City; 🇺🇸 Kansas City, Missouri, United States

Rockhurst University; 🇺🇸 Kansas City, Missouri, United States