Simulation-informed Modelling and Personalized Evaluation (SIMPLE): A Computational Study of MRI-based Brain Age Matrices
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Estimated brain age
研究概览
简要总结
Multimodal magnetic resonance imaging (MRI), detecting brain structural and functional changes, has emerged as a powerful and promising technique to study individual's brain, as T1-weighted scans can detect morphometric features, diffusion tensor imaging (DTI) scans can quantify structural connectivity, and functional MRI can capture the features of functional connectivity. Notably, with the advances in quantitative methods, computational models of brain age and brain-predicted age difference (brain-PAD) detecting the ageing effects on individual's brain features are becoming increasingly popular in clinical studies, which might revolutionize the diagnostic and prognostic phonotypes of age-related brain diseases globally.
详细描述
The score of brain-PAD has threefold explanations: a. negative score representing decelerated brain ageing (brain age<chronological age); b. positive score representing accelerated brain ageing (brain age>chronological age); c. score equal to zero, representing normal brain ageing (brain age=chronological age). The score of brain-PAD indicates the brain ageing pattern with the interaction of lifestyle and cognitive status at individual level. For example, based on structural MRI scans, a younger brain age or a negative score of brain-PAD was found to be associated with better cognition, which indicates the potential utilities of brain age matrices in predicting individual's cognitive maintenance and healthy longevity
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chinese old adults are the ones who are over 60 years of chronological age.
- •Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.
排除标准
- •History of bipolar disorders or psychosis.
- •History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
- •Unable to participant magnetic resonance imaging (MRI) scanning.
结局指标
主要结局
Estimated brain age
时间窗: Baseline
Using the structural and functional connectivity, individual's brain age is calculated based on the connectivity features of core brain networks.
Cognitive maintenance
时间窗: Baseline
The dynamic change of cognitive status is used to evaluate cognitive maintenance. The performance of global cognition is used to determine the cognitive status, including mild neurocognitive disorder (NCD) and major NCD. The global cognition is measured by mini-mental state examination (MMSE).
Plasma β-amyloid
时间窗: Baseline
The levels of Aβ42 and Aβ40 in the plasma samples will be quantified by enzyme-linked immunosorbent assay.
次要结局
- Complex attention(Baseline)
- Memory and learning(Baseline)
- Brain-predicted age difference (brain-PAD)(Baseline)
- Executive function(Baseline)
研究者
LU Hanna
Assistant Professor
Chinese University of Hong Kong