Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
Overview
- Phase
- Phase 4
- Intervention
- Methylphenidate
- Conditions
- ADHD - Combined Type
- Sponsor
- Johns Hopkins University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- BOLD signal during response inhibition
- Status
- Recruiting
- Last Updated
- 6 months ago
Overview
Brief Summary
The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •right handed
Exclusion Criteria
- •pregnant or breast feeding
- •past or current neurological disorder
- •non-ADHD cause of cognitive impairment
- •uncontrolled medical disorder
- •head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma
- •having an adverse reaction to methylphenidate, or other stimulant medication
- •having a contraindication to MRI
- •current smoking
Arms & Interventions
Methylphenidate first
Single oral dose of methylphenidate (10mg or 15 mg) and then matching placebo after washout period of one week.
Intervention: Methylphenidate
Methylphenidate first
Single oral dose of methylphenidate (10mg or 15 mg) and then matching placebo after washout period of one week.
Intervention: Placebo
Placebo first
Matching placebo and then single oral dose of methylphenidate (10mg or 15 mg) after washout period of one week.
Intervention: Methylphenidate
Placebo first
Matching placebo and then single oral dose of methylphenidate (10mg or 15 mg) after washout period of one week.
Intervention: Placebo
Outcomes
Primary Outcomes
BOLD signal during response inhibition
Time Frame: Approximately 90 minutes after dose
BOLD signal (brain activity during fMRI, arbitrary units) in the anterior cingulate cortex during response inhibition.
Glutamate level in the anterior cingulate cortex
Time Frame: Approximately 2 hours after dose
Glutamate level (measured by MRS, institutional units) in the anterior cingulate cortex.