Effect of Caffeine on Time to Anesthetic Emergence After Laparoscopic Cholecystectomy : Randomized-controlled Trial
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- anesthetic recovery time
研究概览
简要总结
A faster emergence from general anesthesia has a double medico-economic impact by reducing the risks of complications and optimizing the performance of surgical units. No drug has been retained for its ability to actively accelerate anesthetic emergence by antagonizing hypnotics. Thus, the aim of this study was to examine the effect of caffeine on the time to emerge from sevoflurane anesthesia for laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American society of Anesthesiologists (ASA) I and II patients, aged older than 18 years old and scheduled for laparoscopic cholecystectomy
排除标准
- •Patient with an allergy to caffeine citrate and analgesics used during postoperative period, those with severe renal or hepatic failure, those who refused to participate in addition to patient with heart rhythm disorder, seizure disorder, hypertension, alcoholic or psychiatric illness
研究组 & 干预措施
GC group
received 300 mg of caffeine citrate infusion
干预措施: 300 mg of caffeine citrate infusion (Drug)
GS group
Equivalent saline infusion
干预措施: Placebo (Drug)
结局指标
主要结局
anesthetic recovery time
时间窗: Postoperative
time to return to spontaneous breathing, eye opening on verbal command and time for extubation
次要结局
- postoperative rehabilitation(24 hours postoperatively)
- postoperative pain (Visual Analog Scale score 0 "no pain" to 10 "severe pain") and consumption of morphine(24 hours postoperatively)
- plasma caffeine levels at H1 and H24(Hour 1 and Hour 24)
研究者
Daghmouri Mohamed Aziz
Principal investigator
Tunis University