Caffeine Intake Inrelation to Perioperative Analgesic Consumption

Completed

• Conditions: Analgesia; Caffeine
• Interventions: Dietary Supplement: Caffeine intake in mg

• Registration Number: NCT05330754
• Lead Sponsor: Ain Shams University

Brief Summary

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood.

We designed this prospective observational study to determine if caffeine consumption would influence intraoperative analgesic consumption

Detailed Description

Caffeine is a well-known natural compound present in various plant products. Caffeine is an integral component of several daily drinks, including tea, coffee, soft drinks, and energy drinks \[1\]. (e consumption habits of these caffeinated drinks have facilitated the wide distribution of and dependence on caffeine. For instance, 89% of the US adult population has an average caffeine intake of 200 mg/day \[2\]. Among the multiple effects and side effects, caffeine also has an analgesic action and is used to reduce pain in several pharmaceutical forms as an adjuvant \[1\]. Several studies have reported a role for caffeine in controlling pain and suggested that caffeine may block the central processing of pain signals in the brain and enhance the body's natural pain resistance pathways \[3\]. In addition, Overstreet et al. found that habitual caffeine consumption diminishes pain sensitivity in a laboratory setting \[4\]

Study Timeline

• Study First Submitted: 2022-04-08
• Study First Submitted QC: 2022-04-08
• Study First Posted: 2022-04-15
• Study Start: 2022-04-20
• Primary Completion: 2022-08-30
• Study Completion: 2022-09-10
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-15
• Last Update Posted: 2022-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients scheduled to undergo elective laparoscopic surgery

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Exclusion Criteria

• Patients converted to an open surgery, postoperative complications that increased postoperative pain, and those with psychological or nervous system diseases were also excluded. Liver disease

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Safe level Group	Caffeine intake in mg	Caffeine daily intake ≤200 mg/day
Unsafe level group:	Caffeine intake in mg	Caffeine daily intake \>200 mg/day
Control group	Caffeine intake in mg	No caffeine intake

Primary Outcome Measures

Name	Time	Method
total intraoperative fentanyl consumption in microgram	2 hours	Amount of total intraoperative fentanyl consumption in microgram

Trial Locations

Locations (1)

Ain Shams University Hospitals; 🇪🇬 Cairo, Egypt