Comparison of Effectiveness Between the Combination of Lidocaine Sprayed at Laryngeal Inlet and on the Cuff of Endotracheal Tube Versus Intravenous Lidocaine for Reducing Cough During Extubation: A Prospective Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 164
- 试验地点
- 1
- 主要终点
- Change in incidence of coughing
研究概览
简要总结
Coughing during extubation of endotracheal tube (ETT) is a common problem that leads to poor surgical results including hemodynamic change, rebleeding at the surgical wound and wound dehiscence. Recently, lidocaine has been introduced for reducing coughing during extubation. However, data comparing routes of lidocaine application are lacking, thus, this study compared the combination of lidocaine sprayed on laryngeal inlet and cuff of ETT versus intravenous lidocaine injection for efficacy in reducing coughing
详细描述
A prospective randomized control trial was conduct with 164 patients. They were randomly allocated into Gr. A and B. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation. The same general anesthesia protocol was applied in all of the patients. Incidence and severity of cough during extubation was evaluated. Furthermore, incidence of 24-hour postoperative adverse events (including sore throat, dysphagia, and hoarseness) and hemodynamic response after extubation were analyzed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
The study based on a sequentially numbered list were prepared in the same way. Participant and outcome assessor were blined to the computer generated lists
入排标准
- 年龄范围
- 19 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who underwent elective surgery with American Society of Anesthesiologists physical status classifications of I and III
排除标准
- •patients having body mass index more than 35 kg/m2, high risk of aspiration, chronic smokers more than ten pack-years, chronic cough or recent upper respiratory infection, suspected difficult airway, retained ETT prior surgery, surgery at oral cavity, neck and thoracic region, operative time more than 120 minutes or less than 30 minutes, and history of lidocaine allergy
研究组 & 干预措施
the study group (Group A)
Patients received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet
干预措施: 10% lidocaine sprayed (Drug)
Comparator group (Group B)
Patients received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation
干预措施: 2% lidocaine intravenous (Drug)
结局指标
主要结局
Change in incidence of coughing
时间窗: the incidence was recorded during extubation and immediatly extubation
Coughing event was recorded by blinded anesthesiologist
次要结局
- Severity of coughing(the severity was recorded during extubation and immediatly extubation)
- Incidence of postoperative sore throat(the incidence was recorded within 24 hr after extubation)
- Incidence of dysphonia(the incidence was recorded within 24 hr after extubation)
- Incidence of dysphagia(the incidence was recorded within 24 hr after extubation)
研究者
Pornthep Kasemsiri
Clinical Associate Professor
Khon Kaen University