Evaluation of the Impact of Laterality on Cerebral Activation During a Virtual Mirror Therapy Task of Upper Limb Using fNIRS Technology in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Mean change in the concentration of oxyhemoglobin during the task
研究概览
简要总结
The aim of this study is to investigate the differences in brain activation in healthy subjects during virtual mirror therapy tasks, depending on the laterality of the task. It seems that mirror therapy-related brain activation is greater when the visual feedback represents the non-dominant hand. The aim of this study is to highlight brain activation profiles during the use of virtual mirror therapy according to the lateralization of the feedback.
详细描述
Stroke frequently leads to upper limb deficit. The recovery of motor skills depends on many factors including laterality. The literature shows that cerebral activation during motor tasks differs depending on whether one is right-handed or left-handed and whether one uses the dominant hand or not. These differences probably lead to different recovery mechanisms depending on the side of the lesion and the laterality. An imaging technique is particularly suitable for exploring these different mechanisms: fNIRS (Functional Near Infra Red Spectroscopy). This method allows (like fMRI) to study cerebral neurovascular coupling. It is based on the fact that an activated brain region increases its local blood flow. Oxygenated (HbO) and deoxygenated (HbR) hemoglobin absorb infrared light and it is then possible to identify the cerebral cortical regions involved in a given task. This technique therefore makes it possible to study cerebral activation under more ecological conditions than fMRI and is thus particularly suitable for exploring rehabilitation techniques.
This research aims to study and compare in healthy subjects, using an fNIRS apparatus, the brain regions involved in a virtual mirror therapy task according to the laterality of the task.
The investigations will be carried out by the principal investigator or by specialized technicians from the neurology functional exploration department.
The acquisition has a duration of 15 minutes, it begins with a rest period of 120 seconds, which corresponds to the baseline. two different tasks are performed during the acquisition for each subject:
- observation of visual feedback of the right hand (RVF)
- observation of visual feedback of the left hand (LVF)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age:18 to 60
- •Right handed
- •No neurological disease
排除标准
- •Person under tutorship or curatorship
- •Known allergy to components of the fNIRS device: neoprene
结局指标
主要结局
Mean change in the concentration of oxyhemoglobin during the task
时间窗: Baseline
Changes in the concentration of oxyhemoglobin during the task measured with fnirs device
Mean change in the concentration of deoxyhemoglobin during the task
时间窗: Baseline
Changes in the concentration of deoxyhemoglobin during the task measured with fnirs device
次要结局
- Compare the feelings of the subjects(Baseline)
- Compare the cortical regions involved during the different mirror therapy tasks(Baseline)