Characterizing the Synergistic Effects of Physical and Cognitive Training on Attention and Working Memory
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 2
- 主要终点
- mCPT (Derived From Test of Variables of Attention (T.O.V.A.))
研究概览
简要总结
The primary goal of this project is to evidence potential synergistic benefits on cognitive control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a complimentary fashion. Healthy adults will be recruited for a longitudinal experiment and randomly assigned to one of four study groups to mechanistically tease apart the possible presence of any synergistic effects on cognitive abilities through the combination of cognitive & physical challenges.
详细描述
Cognitive control functions (e.g. attention, working memory, goal-management) dictate our ability to learn and accomplish selected behavioral goals, with deficiencies in these processes found in a range of mental illnesses. The primary goal of this project is to evidence potential synergistic benefits on cognitive control processes using a video game ("Body-Brain Trainer", or BBT) that integrates cognitive and physical challenges in a complimentary fashion. Healthy adults will be recruited for a longitudinal experiment and randomly assigned to one of four study groups: 1) BBT, 2) "Brain Training" (BBT played with a gamepad controller), 3) "Body Training" (BBT without any cognitive demands), and 4) an expectancy matched placebo control group. Individuals will engage in eight weeks of training within our Neuroscape Laboratory, with pre- and post-training assessments evaluating physical, cognitive, and neural measures. The completion of this project will result in a more sophisticated understanding of how the integration of cognitive and physical training potentially impacts cognitive control processes, setting the stage for more effective interventions for mental illness and learning-related impairments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Can walk briskly for at least 15 minutes continuously without stopping
- •Can stand up from a chair without using your hands
- •Available to come 3x/week to our UCSF Mission Bay laboratory for 8 weeks
- •Willing and able to undergo MRI, EEG procedures
- •English fluency
排除标准
- •cardiac problems
- •bypass surgery
- •pacemaker or heart valve replacement
- •respiratory conditions
- •head trauma with loss of consciousness for less than a few minutes
- •severe head trauma with loss of consciousness for more than a few minutes
- •high/low blood pressure
- •kidney failure
- •electroconvulsive therapy (ECT)
- •implanted electrodes
- •cancer/chemotherapy/radiation
- •irritable bowel syndrome
- •back problems
- •claustrophobia
- •Having been diagnosed with a psychiatric or neurological disorder
- •Use of an assistive device (e.g., cane or walker) at any time to assist with ambulation
- •Joint problems causing significant pain upon movement
- •Heart Disease or Cardiovascular Disease
- •Respiratory Disease (Lung Disease)
结局指标
主要结局
mCPT (Derived From Test of Variables of Attention (T.O.V.A.))
时间窗: At baseline and following the intervention (these data were collected no more than 1 week after intervention period ended, thus approximately 9 weeks after baseline data were collected)
A change from baseline regarding measurement of sustained attention and impulsivity abilities
次要结局
- Delayed Recognition Working Memory Task: Response Time Variability Prior to and 9-weeks After Baseline(At baseline and following the intervention (these data were collected no more than 1 week after intervention period ended, thus approximately 9 weeks after baseline data were collected))