Multimodal Intravenous Analgesia Using Half-dose of Ketamine, Lidocaine and Magnesium Sulfate Provides Efficient Postoperative Analgesia for Patients Undergoing Major Abdominal Surgery: Randomized, Case-controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) in post-Operative follow up.
研究概览
简要总结
Postoperative pain remains a prevalent concern despite ongoing improvements in surgical methods and pain management strategies. Opioids, while commonly prescribed, frequently lead to undesirable side effects. Epidural analgesia, though a viable option, carries its risks and complications. Recent research indicates that combining intravenous lidocaine and ketamine can significantly alleviate postoperative pain and decrease the reliance on opioids within the initial 24 hours following surgery. This approach offers a promising alternative with minimal additional adverse effects, suggesting a potential shift in pain management practices.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 35 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were assigned for surgical intervention;
- •Patients of ASA grade I-III;
- •Patients were free of exclusion criteria;
排除标准
- •Patients who are not in ASA grade I-III;
- •Patients who had uncontrolled hypertension and/or diabetes mellitus;
- •Patients who had uncompensated cardiac, renal, or hepatic diseases;
- •Patients with coagulopathy, spinal deformity, allergy, or contraindication for the used drugs;
- •Patients who refused to sign the informed consent were excluded from the study.
研究组 & 干预措施
Epidural Group
干预措施: epidural analgesia (Drug)
Multimodal Group
干预措施: Multimodal IV analgesia (Drug)
结局指标
主要结局
Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) in post-Operative follow up.
时间窗: 3 months
Value of Multimodal injection in Pain Reduction post operatively manifested by recurrence of pain.
次要结局
未报告次要终点
研究者
Eman M Elafifi
Lecturer of Anesthesia, Pain & ICU
Benha University