NCT07822009尚未招募不适用
The Effect of Total and Partial Sleep Deprivation on Brain Function and Cognitive Functioning In Healthy, Younger Adults.
Örebro University, Sweden1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2026年9月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Brain functional activity and connectivity (PVT)
研究概览
简要总结
This study aims to examine how total and partial sleep deprivation affect brain function, cognitive performance, and biomarkers related to stress and inflammation in the same participants using a crossover design. The study will also compare the effects of total and partial sleep deprivation to determine whether these conditions affect the brain and body differently. The findings may improve our understanding of the consequences of sleep deprivation and help inform strategies to reduce its negative impact on health and society.
- How does total versus partial sleep deprivation affect brain activity during rest and cognitive tasks?
- How does sleep deprivation affect functional connectivity between brain networks?
- How does sleep deprivation affect working memory, attention, and executive control?
- How does sleep deprivation affect biomarkers of stress and inflammation, such as cortisol?
- Are changes in brain activity and connectivity associated with changes in cognitive performance and biological markers?
- Can combining MRI-based and non-MRI-based measures provide a more complete picture of the effects of sleep deprivation?
Participants will complete three study conditions in a randomized order:
Total Sleep Deprivation (TSD): 28 to 32 hours of continuous wakefulness. Partial Sleep Deprivation (PSD): sleep restricted to 4 hours per night for two consecutive nights.
Normal Sleep (control condition): a night of habitual sleep without sleep restriction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent prior to any study-related procedures.
- •Age 20 to 40 years.
- •Normal weight at screening, defined as a BMI between 18.5 and 24.
- •Willingness to comply with the study protocol.
排除标准
- •Current diagnosis of a psychiatric or neurological disorder or syndrome.
- •Current diagnosis of another medical condition that limits study participation.
- •Diagnosed sleep disorder (e.g., insomnia).
- •Self-reported poor sleep quality (>5 on the PSQI).
- •Working permanent night shifts or rotating night shifts.
- •Use of medications or dietary supplements considered likely to affect the study outcome measures (e.g., melatonin).
- •Extremely high perceived stress (>26 on the PSS).
- •Sleep apnea.
- •Excessive alcohol consumption (>9 standard drinks per week or >3 standard drinks per occasion).
- •Extreme morningness or eveningness (>69 or <31 on the MEQ).
- •Excessive daytime sleepiness (>10 on the ESS).
- •Lifestyle factors that may contribute to fragmented sleep (e.g., being a parent of young children).
- •MRI contraindications: claustrophobia; shunts in the head; bullet fragments or metal fragments in the body; metal implants or electrodes in the body; left-handedness; previous head surgery; previous heart surgery; or ingestion of a video capsule that may remain in the gastrointestinal tract.
- •Any other reason that, in the opinion of the investigator, makes participation inappropriate.
研究组 & 干预措施
Normal sleep
Other
干预措施: Normal sleep (Behavioral)
Total Sleep Deprivation
Other
干预措施: Total sleep deprivation (Behavioral)
Partial Sleep Deprivation
Other
干预措施: Partial sleep deprivation (Behavioral)
结局指标
主要结局
Brain functional activity and connectivity (PVT)
时间窗: 3 weeks
Compare normal sleep to SD (total and partial)
次要结局
- Assessment of subjective sleepiness using the Karolinska Sleepiness Scale (KSS)(3 weeks)
- Brain functional activity and connectivity (EMOREG)(3 weeks)
- Brain functional activity and connectivity (PVT) - SD(3 weeks)
- Brain functional activity and connectivity (NBACK)(3 weeks)
- Brain functional activity and connectivity (MST)(3 weeks)
- Brain functional activity and connectivity (SST)(3 weeks)
- Resting state fMRI(3 weeks)
- Structural MRI(3 weeks)
- Diffusion tensor imaging(3 weeks)
- Cognitive function (NBACK)(3 weeks)
- Cognitive function (MST)(3 weeks)
- Cognitive function (SST)(3 weeks)
- Cognitive function (EMOREG)(3 weeks)
- Levels of inflammatory markers (e.g. high sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha)(3 weeks)
- Levels of neural function markers (e.g. brain derived neurotrophic factor (BDNF)(3 weeks)
- Salivary biomarkers (e.g., melatonin and cortisol)(3 weeks)
- Electrophysiological measures (e.g., ECG)(3 weeks)
- Assessment of psychological health using Hospital Anxiety and Depression Scale (HADS)(3 weeks)
- Assessment of psychological health using Pittsburgh Sleep Quality Index (PSQI)(3 weeks)
- Assessment of psychological health using Perceived Stress Scale (PSS)(3 weeks)
- Assessment of sleep quality and sleep disturbances using the Karolinska Sleep Questionnaire (KSQ)(3 weeks)
- Assessment of daytime sleepiness using the Epworth Sleepiness Scale (ESS)(3 weeks)
- Assessment of chronotype (morningness-eveningness preference) using the Reduced Morningness-Eveningness Questionnaire (rMEQ)(1)
- Assessment of sleep-related positive and negative affect using the Negative and Positive Affect Scale for Sleep (NAP-AS)(3 weeks)
研究者
Robert Brummer
Professor
Örebro University, Sweden
研究点 (1)
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