RBR-5q4gm5b招募中3 期
Double-blind, randomized, controlled study on the effect of Sacubitril/Valsartan in the prevention of cardiotoxicity in high-risk patients undergoing chemotherapy with anthracyclines
Hospital Erasto Gaertner0 个研究点开始时间: 2022年3月7日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Intervention
入排标准
- 年龄范围
- 18Y 至 0（—）
入选标准
- •Patients diagnosed with cancer who will undergo chemotherapy with anthracyclines and who have an increase in ultrasensitive troponin I above the 99th percentile after any chemotherapy session; age over 18 years; patients who sign the Free and Informed Consent Term
排除标准
- •Inability to analyze ventricular function; claustrophobia; history of chemotherapy or radiotherapy; previous symptoms of heart failure; presence of cardiomyopathy ou coronary artery disease; moderate to severe aortic or mitral valve disease; contraindication to the use of Sacubitril/Valsartan such as a history of angioedema, renal artery stenosis; creatinine clearance <30ml/min/m2; serum potassium >5.0mEq/L; pregnant women; systolic blood pressure <100mmHg; use of angiotensin converting enzyme inhibitor, angiotensin receptor blocker, Sacubitril/Valsartan, or beta-blocker; implantation of pacemaker not compatible with MRI; patients with HER 2 expression; patients with frailty or at medium-high risk of hospitalization with substantial change in chemotherapy regimen
研究者
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