Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- the ratio of tidal volume in the BAL side and the other side
研究概览
简要总结
ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with invasive mechanical ventilation;
- •Patients who diagnosed with ARDS according to the Berlin definition
- •There are indications for bronchoalveolar lavage
排除标准
- •Patients with contraindications for EIT procedures;
- •Patients with contraindications for RM;
- •Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD);
- •Refusal to sign informed consent
研究组 & 干预措施
RM after BAL
patients underwent RM after BAL
干预措施: Recruitment Maneuver (Other)
Non-RM after BAL
patients did not undergo RM after BAL
结局指标
主要结局
the ratio of tidal volume in the BAL side and the other side
时间窗: up to 24 hours
distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side
次要结局
- respiratory system compliance (the tidal volume to the driving pressure ratio)(up to 24 hours)
- partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio(up to 24 hours)
研究者
Ling Liu
Director of Intensive Care Unit, Principal Investigator, Clinical Professor
Southeast University, China