Meibomian Gland Dysfunction (MGD) and Tear Cytokines After Cataract Surgery According to Preoperative Meibomian Gland Status
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- inflammatory tear cytokine concentration
研究概览
简要总结
To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), the investigators evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •males or non-pregnant females aged between 55 to 80 years-old.
排除标准
- •had a history of ocular diseases, such as ocular infection, ocular allergy, and autoimmune disease, as well as patients with continuous use of topical ocular medications before surgery, or histories of ocular surgery or ocular injury.
结局指标
主要结局
inflammatory tear cytokine concentration
时间窗: 1 month after cataract surgery
comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay
ocular surface staining
时间窗: 1 month after cataract surgery
tear film break-up time,
时间窗: 1 month after cataract surgery
conjunctival injection,
时间窗: 1 month after cataract surgery
Schirmer's test I
时间窗: 1 month after cataract surgery
ocular surface disease index
时间窗: 1 month after cataract surgery
次要结局
未报告次要终点