Effect of Physical Inactivity on Endothelial Function
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Reactive hyperemia in the femoral artery
研究概览
简要总结
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses. Subjects will be randomized to treatment with salsalate or placebo for four days prior to initiation of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment with salsalate will be associated with protection again the development of glucose intolerance and vascular dysfunction in this setting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Pregnancy
- •History of Coronary Artery Disease
- •Diabetes Mellitus
- •Hypertension
- •Cigarette smoking
- •History or family history of deep vein thrombosis or pulmonary embolism
- •Abnormal renal function
- •Liver function tests greater than two times the upper limit of normal
- •Use of viagra or other PDE5 inhibitor
- •Hypercholesterolemia
- •Aspirin allergy/sensitivity
- •Asthma with nasal polyps
- •Peptic ulcer disease/Gastrointestinal bleeding
- •Any ongoing drug treatment
研究组 & 干预措施
Salsalate
Salsalate
干预措施: salsalate (Drug)
Placebo
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Reactive hyperemia in the femoral artery
时间窗: 5 days
次要结局
- Reactive hyperemia in the brachial artery(5 days)
- Oral glucose tolerance test(5 days)
研究者
Naomi M Hamburg
Principal Investigator
Boston University