A study comparing the analgesic efficacy of single dose of epidural morphine Vs epidural morphine with ketamine in patients undergoing lumbar laminectomy with or without discectomy - A randomized controlled clinical trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Time Taken to Receive First Rescue Analgesia
研究概览
简要总结
post operative pain is an important factor that affects recovery after surgery , epidural administration of opioids have been proven to be effective in managing post OP pain . epidural administration of NMDA antagonist has been shown to prolong post OP analgesic and reduce opioid induced central centralization of pain , prevent opioid induced hyperalgesia and opioid tolerance . in this study we are comparing administration of epidural morphine and epidural morphine with ketamine to know which provide better analgesia in post OP lumbar laminectomy patients - in terms of time to receive rescue analgesia , total amount of rescue analgesic received . improves NRS scale .
研究设计
- 研究类型
- Interventional
- 分配方式
- Stratified block randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)(—)
- 性别
- All
入选标准
- •ASA I AND II
- •Patients Undergoing Lumbar Laminectomy And Discectomy Surgery
- •Normal Renal Functions.
排除标准
- •ASA III OR IV
- •Impaired Renal Function
- •Intraoperative CSF Leak
- •Any Contraindications to Morphine and Ketamine.
结局指标
主要结局
Time Taken to Receive First Rescue Analgesia
时间窗: 3 Hours
次要结局
- 1. NRS score 1-10(2. Total Amount of Rescue Analgesic Consumed: Cumulative opioid Consumption)
