Goal-directed heart rate control during emergence from anesthesia using esmolol to attenuate myocardial injury in patients undergoing non-cardiac surgery

Medical University of Vienna, Department of Anaesthesia, General Intensive Care and Pain Management0 个研究点目标入组 140 人开始时间: 2015年8月27日最近更新: 2018年8月20日

适应症

试验速览

暂无简介。

•= 45 years
•scheduled for elective major non-cardiac surgery
•general anesthesia (using general anesthetic drug(s) and opioids)
•anticipated postoperative hospital stay for > 2 days
•no treatment with ß-receptor blocking drugs for more than 30 days
•increased cardiovascular risk because of history of coronary artery disease or a combination of = 2 of the following risk factors: = 70 years, congestive heart failure (NYHA = II), chronic renal failure, smoking history, hypertension, diabetes, lipid-lowering drug treatment or hypercholesterolemia, and obesity (BMI > 35).
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 50
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 90

•patients who do not understand the informed consent
•spinal or epidural anesthesia
•history of ischemic cerebrovascular disease
•severe asthma and COPD
•preoperative heart rate <61 beats per minute (bpm)
•cardiac pacemaker
•atrioventricular block type 2 and 3
•sick sinus syndrome
•sinoatrial block
•cardiogenic shock
•congestive heart failure (NYHA III or IV)
•pulmonary hypertension
•untreated pheochromocytoma
•pulmonary edema
•persons with increased vulnerability (e.g. cognitive limitations)
•pregnant, or breast-feeding
•current administration of cardiodepressant calcium channel antagonists, cardiac glycosides (digoxin, digitoxin) ), or If-inhibitors (such as ivabradin)
•end-stage liver disease
•intolerances or hypersensitivity reactions to study drug
•previous participation in the study
•participation in another, possibly interfering trial

发起方

Medical University of Vienna, Department of Anaesthesia, General Intensive Care and Pain Management