Observational Study of Changes in Plasma and Intestinal Mucosa Lipid Profiles in Patients With Inflammatory Bowel Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Differential lipid composition between disease and healthy groups
研究概览
简要总结
This study aimed to demonstrate the characteristic lipid profile changes in patients with inflammatory bowel disease.
详细描述
This study aimed to demonstrate the characteristic lipid profile changes in patients with inflammatory bowel disease.
The investigators followed up with patients with different stages of IBD and collected plasma and lesion tissues from patients and healthy volunteers for lipid metabolism-related substances to assess the changes in lipid metabolism in patients with different stages of IBD and their impact on disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with inflammatory bowel disease; aged 18-80 years; all cases agreed to participate in the study.
- •Healthy volunteers who agreed to participate in the study.
排除标准
- •Patients with severe heart disease; patients with severe kidney disease; patients with low blood pressure; patients with severe infections such as sepsis or pneumonia; patients who have used immunosuppressants such as 6-mercaptopurine, imidazole thiopurine, and cyclosporine within a short period, and women during pregnancy; patients who are post-colon resected; patients who disagreed to participate in the study.
结局指标
主要结局
Differential lipid composition between disease and healthy groups
时间窗: 14 weeks
Differences in lipid composition between disease and healthy groups.
Differences in lipid composition between active and remission disease
时间窗: 14 weeks
Differences in lipid composition between active and remission disease
次要结局
未报告次要终点
研究者
Hongyu Xu
Chief of the GI department
First Affiliated Hospital of Harbin Medical University