Natural Disease Progress of Dupuytren Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 261
- 试验地点
- 1
- 主要终点
- The course of DD: passive and active extension deficit and dimension of palpable nodules and cords
研究概览
简要总结
Dupuytren disease (DD) is a progressive fibromatosis of the palmar fascias of the hand and fingers, which may lead to extension deficits of the fingers. The disease can be very disabling in moderate and severe cases, whereby performing normal daily activities can become very problematic. The aetiology and pathogenesis are not completely understood. There is a genetic disposition and it is influenced by environmental factors. The disease is especially prevalent in white males of Northern European descent above 50 years of age. There is paucity of knowledge about the natural progression of the disease. Several studies have been conducted on progression of disease and from these studies it becomes obvious that the disease is progressive over several years. However, in most studies only one moment of follow-up has taken place, so the course of the progression over time is unknown.
The aim of this study is to enhance our knowledge on the natural disease progression of DD at different stages.
详细描述
Objective
- Primary objective: To study natural disease progress of Dupuytren Disease (DD) in different stages of disease in males and females above 18 years of age.
- Secondary objectives:
- To study the effect of potential risk factors for DD on natural disease progress.
- To study at what stage of disease patients with DD experience problems in daily life.
- To study the incidence and course of recurrent disease. Primary Hypothesis: The natural course of disease is an exponential function of time.
- To study the intrarater reliability of the measurements
f. To determine whether the echogenicity of the nodules can predict progression g. To determine whether extension deficit measurements can be replaced by measurements of extension, and whether this will facilitate the statistical analysis h. To determine the association between passive and active measurements of extension and extension deficit, and to see whether active measurements can be derived from passive measurements and vice versa.
- Study design: The study is designed as a prospective observational pilot study with a follow-up of 10 years.
- Study population: Males and females above 18 years of age with all stages of primary Dupuytren's disease in at least one hand
- Main study parameters/endpoints: The natural course of progression of DD measured as the increase or decrease in size of nodules and cords in millimetres and/or increase of total passive extension deficit in degrees, from baseline to endpoint.
- Secondary study parameters:
- Patient-reported hand function (Michigan Hand Outcomes Questionnaire (MHOQ), Patient-Rated Wrist/Hand Evaluation (PRWHE) and Unité Rhumatologique des Affections de la Main (URAM) scale
- incidence and course of recurrent disease
- disease activity (ultrasonography and tonometry)
- Procedure Patients visit the outpatient clinic every 6 months (first 5 years of follow-up) and later on every 12 months (last 5 years of follow-up) for an anamnestic interview, physical examination of the hands, ultrasonography, tonometry and for filling out the PROMs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients (> 18 years of age) with primary Dupuytren's disease in all Tubiana stages
- •Operated hands of patients with primary Dupuytren's disease on the contra lateral hand
排除标准
- •Patients who are incapable of giving consent
- •Patients who are not able or not willing to visit the UMCG for follow-up
- •Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
结局指标
主要结局
The course of DD: passive and active extension deficit and dimension of palpable nodules and cords
时间窗: every 6-12 months
Active and passive extension deficit is measured with a goniometer at joint level Dimension of nodules and cords is measured using a tumorimeter
次要结局
- Disease activity: Echogenicity and nodule hardness(every 12 months, starting from 2016 (ultrasound) and 2018 (tonometry))
- Patient-reported hand function: MHQ, PRWHE and URAM(every 6-12 months)
研究者
D.C. Broekstra
PhD
University Medical Center Groningen