Assessment of Left Ventricle Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery as an Early Indicator of Cardiac Failure. Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in left ventricle diastolic function in time
研究概览
简要总结
Patients scheduled for Thoracic Endovascular Aortic Repair (TEVAR) surgery will have transthoracic echocardiography evaluation of left ventricle diastolic function during the perioperative period.
详细描述
Patients undergoing TEVAR surgery are a high risk group of developing perioperative cardiovascular complications.
Left ventricle diastolic dysfunction is common in this group of patients because of the prevalence of risk factors: > 60 years old, hypertension, smoking history and diabetes.
Because of many predisposing factors that occur during the surgery: stress respond, fluid shifts, anaesthesia and mechanical ventilation. Deterioration of the diastolic function is likely to occur in perioperative period
In this study, the investigators will evaluate change in left ventricle diastolic function as a marker for early detection of a myocardial failure in patients scheduled for an elective TEVAR surgery. The examination will be performed preoperatively, shortly after the surgery and 24 hours after the surgery.
Aim: The aim of the study is to evaluate the diastolic function of left ventricle in perioperative period after high risk surgery. This may provide a valuable information in preoperative risk stratification and postoperative therapy guidance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled TEVAR
- •>60 years old
排除标准
- •Atrial fibrillation or other non-sinus rhythms
- •Atrioventricular blocks
- •Heart rate change more than 25% postoperatively
- •Not adequate transthoracic view
- •Postoperative shock
结局指标
主要结局
Change in left ventricle diastolic function in time
时间窗: Baseline, 2 hours and 24 hours
Echocardiographic assessment of change in left ventricle diastolic function repeated in time intervals: Baseline before the surgery, 2 and 24 hours after the surgery
次要结局
- Change in biochemistry markers: troponins(Baseline, 2 hours and 24 hours)
- Length of stay in hospital(up to 14 days)
- Change in left ventricle systolic function(Baseline, 2 hours and 24 hours)
- Kidney function(72 hours)
- Fluid balance(72 hours)
- Change in biochemistry markers: brain natriuretic peptide(Baseline, 2 hours and 24 hours)
- Hemodynamic parameters: Heart rate(Baseline, 2 hours and 24 hours)
- Hemodynamic parameters: Systolic and diastolic pressure(Baseline, 2 hours and 24 hours)
- Mortality(up to 30 days)
研究者
Mateusz Zawadka
Principal Investigator
Medical University of Warsaw