Indicators of Gut Permeability in Normal-weight Obesity in Response to Brief, Maximal and Sustained, Submaximal Exercise
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Serum concentrations of FABP2 following short, intense exercise
研究概览
简要总结
Exercise acutely increases gut permeability and inflammation, even in healthy populations. However, whether this response differs in groups at-risk for CVD that present with low-grade inflammation (e.g., normal-weight obesity) has yet to be examined. The investigators aim to measure serum indicators of gut permeability in those with normal-weight obesity pre- and post-short, intense exercise and sustained, moderate exercise
详细描述
The investigator's overall goal is to examine how indicators of gut permeability change in response to exercise in individuals with normal-weight obesity (i.e., normal body mass index [BMI] and high body fat percent) relative to those with a normal BMI and low body fat percent and those with a BMI in the obesity range and high body fat percent.
The investigators will examine indicators of gut permeability (specified in primary outcomes) in response to a short, intense bout of exercise (i.e., VO2 max test on a cycle ergometer) and sustained, moderate bout of exercise (i.e., 45 minutes at 65% measured VO2 max on a cycle ergometer).
Additionally, the investigators will measure basic anthropometrics, blood lipids and glucose, and body composition with DXA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Control group: normal BMI, body fat percentage < 25% (male) or < 35% (female)
- •Normal-weight obesity: normal BMI, body fat percentage > 25% (male) or > 35% (female)
- •Overt obesity: BMI in obesity range, body fat percentage > 25% (male) or > 35% (female)
排除标准
- •Presence of pacemaker
- •Postmenopausal status
- •History of chronically using of tobacco products, illicit drugs, anti-inflammatory drugs (e.g., NSAIDs), lipid lowering drugs
- •Recent use of antibiotics (< 6 weeks) and NSAIDs (< 3 days)
- •Established cardiometabolic disease (e.g., cardiovascular disease, type 2 diabetes) diseases inflammatory in nature (e.g., rheumatoid arthritis, inflammatory bowel disease), and/or diagnosed irritable bowel syndrome.
结局指标
主要结局
Serum concentrations of FABP2 following short, intense exercise
时间窗: Approximately 8 months
The investigators will examine peak and absolute change in this indicator of gut permeability after the VO2 max test on a cycle ergometer.
Serum concentrations of IL-6 following sustained, moderate exercise
时间窗: Approximately 8 months
The investigators will examine peak and absolute change in this inflammatory marker after 45-minutes of exercise at 65% VO2 max on a cycle ergometer.
Serum concentrations of LBP following short, intense exercise
时间窗: Approximately 8 months
The investigators will examine peak and absolute change in this indicator of gut permeability after the VO2 max test on a cycle ergometer.
Serum concentrations of sCD14 following short, intense exercise
时间窗: Approximately 8 months
The investigators will examine peak and absolute change in this indicator of gut permeability after the VO2 max test on a cycle ergometer.
Serum concentrations of FABP2 following sustained, moderate exercise
时间窗: Approximately 8 months
The investigators will examine peak and absolute change in this indicator of gut permeability after 45-minutes of exercise at 65% VO2 max on a cycle ergometer.
次要结局
- Heart rate dynamics during exercise sessions(Approximately 8 months)
- Respiratory exchange ratio (RER) during VO2 max test(Approximately 8 months)
- Maximum workload during exercise sessions(Approximately 8 months)
- VO2 Max(Approximately 8 months)
研究者
Sam Emerson
Associate Professor of Nutritional Sciences
Oklahoma State University