NCT06847685招募中不适用
Mechanisms of Uterine Fluid Absorption During Early Pregnancy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 3
- 主要终点
- Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.
研究概览
简要总结
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Subject must be a healthy woman between the ages of 18 and 45 years.
- •Women with diagnosed endometriosis or infertility (cases).
- •Women without a diagnosis of endometriosis or infertility (controls).
- •Subject must have regular menstrual cycles.
- •Subject must have a body mass index (BMI) between 18 and
- •Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
- •Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
- •No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
- •For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.
排除标准
- •Pregnant women.
- •Study subjects with endometrial cancer.
- •Study subjects with a history of endometrial ablation.
- •Study subjects with undiagnosed uterine bleeding.
- •Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
- •Study subjects with an intrauterine device (IUD).
研究组 & 干预措施
Women between the ages of 18 and 45 years with or without endometriosis
50 women with endometriosis (cases) and 50 without endometriosis (controls)
Women between the ages of 18 and 45 years with or without endometrial cavity fluid undergoing IVF
20 women with endometrial lumen fluid and 20 women without endometrial lumen fluid
结局指标
主要结局
Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.
时间窗: 5 years
Immunolocalization of ion channel levels ENaCα, SLC5A1 and SLC5A3 in endometrial tissues.
次要结局
- Compare relative protein expression of ENaCα, SLC5A1 and SLC5A3 by immunohistochemistry(5 years)
研究者
研究点 (3)
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