Exploring Clinical Management and Outcomes of Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Mortality observed and estimated by predictive indexes
研究概览
简要总结
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™.
Objectives:
Describe the experience and outcomes in patients with sepsis and AKI treated receiving CRRT with the adsorption membrane filter Oxiris™
详细描述
Study Background & Rationale:
Acute kidney injury (AKI) is common in patients with sepsis, occurring in 5-50%. It happens in the context of a critical illness requiring intensive care. Fifteen percent require renal replacement therapy as supportive therapy until the kidneys recover. Membrane-coated filters, such as Oxiris™, promote high filtration clearance of uremic toxins, but additionally removal of inflammatory mediators and bacterial liposaccharide (LPS) . Even though this potential mechanism should be expected to benefit septic and AKI patients, results have not been uniform.
The investigators´ group has been prescribing CRRT for AKI treatment for the last 20 years, having performed more than 20 thousand procedures. The investigators´ group experience with Oxiris™ filter in CRRT started in 2018. The objective of the study is to describe the clinical operational management of CRRT with this kind of filter and to explore patients' outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults (>18 years)
- •Diagnosis of AKI (KDIGO stage 3)
- •Diagnosis of sepsis of any cause
排除标准
- •COVID19 diagnosis
结局指标
主要结局
Mortality observed and estimated by predictive indexes
时间窗: Through study completion, an average of 5 years
In-hospital mortality observed and estimated by the predictive index (SAPS III) during the hospitalization which developed AKI and need CRRT with Oxiris
次要结局
- Renal function recovery at discharge(Through study completion, an average of 5 years)
- Management of hemodynamic drugs during CRRT(Through study completion, an average of 5 years)
- CRRT circuit life-time(Through study completion, an average of 5 years)
- CRRT dependence(Through study completion, an average of 5 years)
- Length of hospital stay(Through study completion, an average of 5 years)
- Hemorrhagic complications during CRRT(Through study completion, an average of 5 years)
- Renal function recovery in medium term(At 30 days after hospital admission in which participants developed AKI)
- Initial renal function recovery(Through study completion, an average of 5 years)
- Dialysis dependence in long term(Through study completion, an average of 5 years)