Double blind randomized placebo controlled trial of corticosteroids and doxycycline in the treatment of interstitial nephritis

one0 个研究点目标入组 200 人开始时间: 待定最近更新: 2024年8月20日

适应症

试验速览

暂无简介。

•1.Two or more elevated (value more than upper limit of the normal) serum creatinine values done within 3 days and
•2.Normal size kidneys defined as more than 9 cm longitudinal diameter and normal anatomy on ultrasound scan
•3. Age less than 60 years

•1.History of chronic kidney disease, diabetes mellitus, chronic hypertension, connective tissue diseases, vacuities,hyperuricemia, pyelonephritis, renal stone disease and any obstructive uropathy, polycystic kidney disease or any other known genetic disease, glomerular nephritides, snake bite, and childhood renal disease.
•2.Whose current abnormal creatinine is explainable by recent exposure to nephrotoxic drugs (non-steroidal anti-inflammatory drugs, gentamicin…etc.) or toxins.
•3.BP >160/100mmhg untreated or >140/90 on up to two antihypertensives
•4.Two or more fasting blood sugar more than 7 mmol/l
•5.UFR showing red blood cells more 50 per HPF with more than 80% dysmorphic cells or nephrotic range proteinuria or pus cells more than 100 per HPF with a positive urine culture
•6.Ultrasound scan revealing unilateral renal involvement

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