Double blind randomised placebo controlled trial of progesterone for the prevention of preterm birth in twins
Not Applicable
Completed
- Conditions
- Preterm deliveryPregnancy and Childbirth
- Registration Number
- ISRCTN35782581
- Lead Sponsor
- Greater Glasgow Health Board (North Glasgow University Hospitals Division) and the University of Glasgow (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 500
Inclusion Criteria
1. Women with twin pregnancy
2. Gestation established by scan before 20 weeks gestation
3. Known chorionicity
Exclusion Criteria
1. Known signficiant structural or chromosomal fetal abnormality
2. Contraindications to progesterone
3. Planned cervical suture
4. Planned elective delivery before 34 weeks gestation
5. Intervention for twin to twin transfusion before 22 weeks
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of women in each group delivering before 34 weeks gestation
- Secondary Outcome Measures
Name Time Method Pregnancy duration, maternal complication rates, neonatal complication rates, maternal side effects, acceptability of treatment, subject perception of alternatives, perinatal mortality, perinatal morbidity