Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients Undergoing Abdominal Aneurysm Repair.
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.
研究概览
简要总结
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?
详细描述
Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery.
Primary outcome:
Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.
Secondary outcome:
Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Patient using corticosteroids, NSAIDs or Cox-II inhibitors
- •Patients under 18 years
- •Patients who are included in pharmaceutical studies
- •Opioids-, benzodiazepines-, antiepileptic drugs-, alcohol- and α2-agonists abuse
- •Pregnant and breastfeeding women
- •Patients with known hypersensitivity for opioids, propofol or volatile anesthetics
- •Patients with serious arrhythmias (atrial fibrillation/flutter is acceptable)
- •Uncontrolled hypertension, serious psychiatric disease
- •Patients with unstable angina pectoris or myocardial infarction the last month before inclusion
- •Acute abdominal aortic surgery (acute dissection or rupture)
- •Planned laparoscopic abdominal aortic aneurysm surgery
- •Transfusion of blood products last month before surgery
- •Glucocorticoid users
结局指标
主要结局
Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.
时间窗: 30 days
次要结局
- Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.(30 days)