The Systemic Availability of Short-Chain Fatty Acids After Delivery in the Small Intestine and the Colon
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Concentration of 13C-short-chain fatty acids in blood
研究概览
简要总结
The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers. The main question it aims to answer is whether the site of administration affects the amount of SCFA that reaches the systemic circulation. On two test days participants will ingest capsules filled with SCFA that are specifically delivered in the small intestine or the colon. After ingestion, blood samples will be collected at regular time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •female and male
- •healthy participants
- •age within 18 - 50 years
- •normal BMI (18.5-25 kg/m^2)
排除标准
- •Chronic gastrointestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, chronic constipation (less than 3 stools a week) and chronic frequent diarrhoea (more than 3 stools a day)
- •Previous abdominal surgery, except from appendectomy
- •Being on a weight loss, gluten-free, lactose-free, or vegan diet
- •The donation of blood during the last 3 months or suffering from low blood haemoglobin levels
- •The use of antibiotics or other medication that affects the gastrointestinal tract 3 months preceding the study and/or during the study
- •The use of prebiotics or probiotics 2 weeks preceding the study and/or during the study
- •Pregnancy, lactation or wish to become pregnant during the study period
- •Previous or current substance/alcohol dependence or abuse (> 2 units per day/14 units per week)
研究组 & 干预措施
small intestinal delivery capsules
Participants will ingest small intestinal delivery capsules filled with short-chain fatty acids.
干预措施: SCFA (Dietary Supplement)
Colon-delivery capsules
Participants will ingest colon-delivery capsules filled with short-chain fatty acids.
干预措施: SCFA (Dietary Supplement)
结局指标
主要结局
Concentration of 13C-short-chain fatty acids in blood
时间窗: up to 12 hours
Assessed by analysing SCFA in blood samples collected at regular time points
次要结局
未报告次要终点