Association Between Plasma Melatonin and Coronary Artery Calcification
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 574
- 试验地点
- 1
- 主要终点
- correlations of CAC score with melatonin concentrations
研究概览
简要总结
The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.
详细描述
Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with angina-like chest pain, were included in this study. All subjects had blood samples collected and all underwent a coronary CTA scan.
排除标准
- •melatonin treatment
- •coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery)
- •heart failure or cardiomyopathies
- •hepatic failure
- •renal dysfunction
- •haemolytic disorders
- •thyroid disease
- •neoplastic diseases
- •acute infectious or inflammatory conditions.
结局指标
主要结局
correlations of CAC score with melatonin concentrations
时间窗: Subjects underwent a CAC scan at baseline.
CAC score was obtained using the coronary CTA and Agatston score.
次要结局
- correlations of CAC score with high-sensitivity C-reactive protein (hsCRP) level(Subjects had blood samples collected at baseline.)
- correlations of CAC score with malondialdehyde (MDA) level(Subjects had blood samples collected at baseline.)
研究者
Chen Wei Ren, MD
Prof.
Chinese PLA General Hospital