Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus
试验速览
- 阶段
- 1 期
- 入组人数
- 37
- 主要终点
- Pain using Numerical rating scale
研究概览
简要总结
Using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of OLP.
详细描述
Oral lichen planus (OLP) is a chronic inflammatory T cell mediated autoimmune disease that affects skin and any mucous membrane particularly oral mucosa.The patient complains of burning sensation, pain; interference with eating, swallowing and speech leading to worsening of quality of life.Oxidative stress plays a role in pathomechanism of OLP disease. Enzymatic and non- enzymatic anti-oxidants act as a physiological guard against reactive oxygen species (ROS) and cytokine-mediated toxicity.Herbal treatment is the aim of the future therapy.Chamomile has anti-oxidant , anti-inflammatory effect and accelerate healing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
The supervisor(AA) will be blind. The principle investigator(EN) will supply the patient with the treatment.
The supervisor (AA) will assess the clinical parameters before treatment , between visits and at the end of the treatment.
Statistician will be blind. Double - blind study.
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic OLP.
- •Patients with no history of taking corticosteroids for the last 6 months.
- •Patients who agree to take medication.
- •Medically free
排除标准
- •Patients with oral lesions other than OLP.
- •Lichenoid reaction .
- •Pregnant females and lactation.
研究组 & 干预措施
topical chamomile
herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect.
干预措施: topical chamomile (Drug)
Topical Triamcinolone Acetonide
topical triamcinolone acetonide is the gold standard treatment of oral lichen planus.
干预措施: topical chamomile (Drug)
结局指标
主要结局
Pain using Numerical rating scale
时间窗: 1 month
Pain measure using Numerical rating scale
次要结局
- clinical sign score(1 month)
研究者
Esraa Nashat
11 saraya st - manial - cairo
Cairo University