The Effect of Modafinil on Neural Processing During the Interference and Feedback Based Learning Task
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Neural processing during the interference processing
研究概览
简要总结
The study aims to examine whether a single dose of modafinil (200mg, p.o.) can affect feedback-based learning and interference processing in healthy male subjects.
详细描述
Based on previous animal and human research suggesting a catecholamine-mediated, potentially pro-cognitive, mechanism of action of modafinil, the present study seeks to explore effects of modafinil on feedback-based learning and interference processing in healthy subjects. To this end, the present randomized double-blind, between-subject, placebo-controlled pharmaco-fMRI experiment plans to determine the behavioral and neural effects of a single dose of p.o.modafinil (200mg) versus placebo on validated feedback-based learning and emotional/non-emotional cognitive conflict paradigms. To control for potential effects of pre-medication personality traits as well as effects of modafinil on subjective task performance, subjects will be administered pre-treatment assessing relevant personality traits and post-treatment assessments of meta-cognitive confidence estimation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders
- •Non-smokers
- •Right-handedness
排除标准
- •Medical or psychiatric illness
- •Allergy against medications or general strong allergies
- •Sleep disorders
- •High blood pressure, general cardio-vascular alterations
- •History of head injury
- •Visual or motor impairments
研究组 & 干预措施
placebo group
a single dose of p.o. placebo (200mg)
干预措施: Placebo Oral Tablet (Drug)
modafinil group
a single dose of p.o. modafinil (200mg)
干预措施: Modafinil Oral Tablet (Drug)
结局指标
主要结局
Neural processing during the interference processing
时间窗: 4h after treatment
fMRI BOLD indices of neural processing in interference related brain regions will be compared between the treatment and placebo group.
Neural processing during feedback based learning
时间窗: 4h after treatment
fMRI BOLD indices of neural processing learning related brain regions will be compared between the treatment and placebo group.
次要结局
- Behavioral interference performance - Response Time(4h after treatment)
- Behavioral interference performance - Accuracy(4h after treatment)
- Behavioral learning performance - Accuracy(4h after treatment)
- Behavioral learning performance - Reaction time(4h after treatment)
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China