Implementation Plan for Prevention and Treatment of Type 2 Diabetes Mellitus and Its Microvascular Complications with Integrated Chinese and Western Medicine in Shandong Province

Shandong Provincial Hospital0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1.In patients with type 2 diabetic nephropathy, persistent albuminuria, 2 consecutive urine tests within 3 months of urine microalbumin/creatinine (UACR) >= 30mg/g;
•2.Glomerular filtration rate eGFR>=45ml/min/1.73m2, and required to remain stable during the trial (eGFR decreased <=25% from the beginning of screening to the second week of follow-up);
•3.Patients with deficiency of qi and yin and blood stasis;
•4.No gender limit, age 18-80 years old, BMI <= 45 kg/m2;
•5.Glycated hemoglobin (HbA1c) 6-11% , fasting blood glucose (FPG) <= 15 mmol/l;
•6.Systolic/Diastolic blood pressure (SBP/DBP) <=180/100 mmHg (sitting position);
•7.Volunteer to participate and cooperate with physicians, sign informed consent.

•1.Recent acute complications of diabetes such as hypoglycemia coma, diabetic ketosis, lactic acidosis, etc.
•2.Patients with heart failure and myocardial infarction; combined infection, immune disease, malignant tumor; combined with liver disease (ALT, AST or ALP levels exceed three times the upper limit of normal);
•3.Male serum creatinine (SCr)>= 1.50 mg or Fmale serum creatinine (SCr) >= 1.40 mg;
•4.People with a history of nephrotic syndrome or inflammatory kidney disease in the past 3 months, or other causes such as excessive exercise, heart failure, infectious febrile diseases, and urinary tract infections that lead to elevated urine microprotein;
•5.Those who have used nephrotoxic drugs and antioxidants within the past 2 weeks, or have been treated with glucocorticoids systemically;
•6.Patients requiring dialysis or kidney transplantation;
•7.History of bariatric surgery or other gastrointestinal surgery causing chronic malabsorption within 2 years;
•8.Patients with drug contraindications: pregnant or breastfeeding women, allergic physiques, and those who are allergic to the drug used in this test;
•9.Epidemiological history;
•10.Others who cannot cooperate, such as mental patients.

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