To compare the efficacy of Topical Beta blocker (0.5% Timolol Maleate) and Ultrapotent Corticosteroid (0.05% Clobetasol Propionate) in the treatment of superficial infantile Capillary Hemangioma (ICH) via Randomized Control Trial: A Single Centre Pilot Study - Nil

All India Institute of Medical sciences, Raebareli, U.P.0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年11月13日

试验速览

暂无简介。

•All children less than <36 months of age having clinical and color Doppler-proven infantile capillary hemangioma (ICH).
•1. Superficial ICH on Doppler, including mucosal surfaces, and ulcerated ICH
•2. Size of lesion > 1.5 Cm
•3.No H/O prior tt for ICH
•4. Patients at risk of adverse effects of systemic beta-blockers like Cardiac arrhythmias, first-degree heart block; recovered pts of cardiogenic or hypotensive shock, sinus bradycardia, Asthma, history of hypoglycemia, birth weight < 2500 g would be included.

•1. Age at the time of enrolment is >36 months
•Dermal invasive ICH
•2. Life-threatening ICH
•3. Persistent arrhythmias, wheezing, heart failure
•4. Associated Visceral vascular (liver/ renal/brain) lesions
•5. Patients Having Raynaud phenomena
•6. Bradycardia below the age-specific range for normal
•7. Low blood pressure according to age-specific ranges for normal
•8. known case of Pheochromocytoma
•9. Breast-feeding mothers who are on treatment with oral propranolol
•10. Renal failure
•11. liver failure
•12. Hyperkalemia
•13. Psoriasis in infant
•14. Infant or mother taking other drugs having synergistic, antagonistic action with beta blockers viz calcium channel blocker (Diltiazem, Verapamil, bepridil), Quinidine, Amiodarone (antiarrhythmic), Digitalis, Lidocaine, Dihydropyridines, Antihypertensives (ACE Inhibitors, angiotensin II-receptors antagonists, diuretics, alpha-blocker, Corticosteroid, (nitrates derivatives, type 5-phosphodiesterase inhibitors, tricyclic antidepressants, antipsychotics, dopaminergic agonists, levodopa, amifostine, baclofen, rifampicin or phenobarbital and Hypoglycaemic agents

发起方

All India Institute of Medical sciences, Raebareli, U.P.