NCT01958411已完成不适用
Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 340
- 试验地点
- 1
- 主要终点
- Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT
研究概览
简要总结
- Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.
- Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT).
- Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population.
- Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy patients for visiting routine medical check in our clinic
排除标准
- •History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
- •Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
- •Malignancy
- •Severe renal or hepatic disease
- •Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin
结局指标
主要结局
Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT
时间窗: 12 weeks
Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT
时间窗: 12 weeks
次要结局
- The relationship of NAFLD with carotid intima media thickness(12 weeks)
- The relationship of epicardial adipose tissue volume with carotid intima media thickness(12 weeks)
研究者
研究点 (1)
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