Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Skin Temperature
研究概览
简要总结
Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1/5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https://doi.org/10.1186/s12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.
Therefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or Female above the age of 19
- •Able to provide informed consent
排除标准
- •History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence
- •Been hospitalized due to COVID-19
- •Pregnant/Breastfeeding
- •Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)
研究组 & 干预措施
Alcohol
Consumption of alcohol beverages: females 0.75 ± 0.1 grams of ethanol/kilogram body mass; males 1.0 ± 0.1 grams of ethanol/kilogram body mass
干预措施: Alcohol (Ethanol) (Drug)
Placebo
Placebo (non-alcoholic beverage)
干预措施: Placebo Beverage (Drug)
结局指标
主要结局
Skin Temperature
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
Mean skin (4 sites)
Core Temperature
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
measured rectally
Blood Pressure
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
ECG-gated blood pressure cuff
Heart Rate
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
3-lead electrocardiogram
Heart Rate Variability
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
Arrythmia presence
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
Whole-body Sweat Loss
时间窗: mass measured at baseline and end heat stress.
Difference in mass from baseline to end heat stress
Postural Sway via the Romberg Test
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
The total movement of the body around the center of mass with feet together
Skin Blood Flow
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
Urine Output
时间窗: Total urine output (e.g. volume) from baseline to immediately following 120 minutes of heat stress
ASHRAE seven-point thermal sensation scale
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
5-Point Thermal Comfort Scale
时间窗: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).
Thermal comfort scale with 1- comfortable and 5 - very uncomfortable
次要结局
- Subjective Blood Alcohol Concentration (visual analog scale 0.0 - 0.20)(measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).)
- Blood Alcohol Concentration(measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).)
研究者
Nicholas Ravanelli
Assistant Professor
Lakehead University