Drug repositioning of donepezil for the treatment of COVID-19 sequelae.Repositioning for the treatment of psychiatric symptoms

akamura Kensuke0 个研究点目标入组 120 人开始时间: 2022年12月14日最近更新: 2024年1月22日

适应症

试验速览

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•1) Patients who are at least 20 years old and less than 75 years old at the time of obtaining consent.
•2) Patients with COVID-19 infection who had upper respiratory tract symptoms or symptoms of fever or cough in the acute phase.
•3)Patients who have a bainarization score over 4 on the Chalder Fatigue Score-11 assessment (pre-observation period assessment).
•4) Patients with COVID-19 infection confirmed positive by antigen or PCR test and within 52 weeks from the onset of COVID-19 infection to randomization.
•5) Patients who have given their consent.

•1) Patients who have been diagnosed or suspected to have a chronic disease with fatigue, such as psychiatric disease or chronic fatigue syndrome that corresponds to F0 to F3 of ICD-10 in the past.
•2) Patients who depend on dialysis or who are likely to start dialysis during the study period.
•3) Patients with liver cirrhosis of Child-Pugh C.
•4) Patients with respiratory diseases such as COPD and interstitial pneumonia (Hugh-Jones classification over II).
•5) Patients with heart failure (NYHA over 2).
•6) Patients who are unable to answer the questionnaire (including cognitive impairment).
•7) Patients with influenza infection.
•8) Patients already taking donepezil or cholinesterase inhibitors.
•9) Patients who are allergic to any component of the study drug.
•10) Patients with a history of hypersensitivity to piperidine derivatives.
•11) Patients who have participated in the same clinical trial in the past.
•12) Patients who do not agree with contraception by themselves or their partner during the study period. Patients who give breast-feeding.
•13) Other patients who are judged to be inappropriate as subjects by the investigator (co-investigator).

发起方

akamura Kensuke