Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 24
- 主要终点
- Change in quadriceps strength via isokinetic dynamometry
研究概览
简要总结
The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. The main questions it aims to answer are:
- To determine if performing RT prior to a period of disuse enhances the regain of strength, skeletal muscle size, and skeletal muscle quality while performing RT after a period of disuse.
- To determine if performing RT prior to a period of disuse dampens the maladaptive effects of disuse on muscle size, muscle quality, and strength.
- To determine the anabolic and proteolytic mechanisms underpinning the observed outcomes.
Participants will:
- Perform either 6 weeks of resistance training or maintain an untrained lifestyle
- Perform 2 weeks of limb immobilization induced disuse of a randomized leg
- Perform 6 weeks of resistance training
Researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18-30
- •Free from medical implants in lower extremity that would interfere with low-dose radiation
- •Are not allergic to ultrasound gel or Lidocaine
- •Have no or minimal experience with resistance training (less than 1 training session/week for a 1 year period)
排除标准
- •Have been exposed to medically necessary radiation in the past 12 months other than dental x-rays
- •Have known overt cardiovascular or metabolic disease
- •Have a medical condition that would contraindicate participating in an exercise program or donating a skeletal muscle biopsy (e.g. blood clotting disorder, taking blood thinners, etc.)
- •Are undergoing medical treatment for a disease that would interfere physiologically or logistically with study outcomes and/or protocols (e.g. undergoing chemotherapy and/or radiation for cancer treatment)
- •Have consumed supplemental protein, creatine, and/or agents that affect hormone status (e.g. testosterone, growth hormone boosters, etc.) within the previous 2 months.
结局指标
主要结局
Change in quadriceps strength via isokinetic dynamometry
时间窗: Through completion of study, 16 weeks
Strength of the quadriceps will be assessed via isokinetic dynamometry
Change in vastus lateralis fiber cross-sectional area
时间窗: Through completion of study, 16 weeks
Upon the procurement and analysis of muscle from the vastus lateralis of participants, histological techniques will be used to assess fiber cross-sectional area of muscle fibers
Change in quadriceps strength via 3 repetition maximum testing
时间窗: Through completion of study, 16 weeks
Strength of the quadriceps will be assessed via 3-repetition maximum testing of select exercises (leg press, leg extension, hex-bar deadlift)
次要结局
- Change in activity of catabolic systems(Through completion of study, 16 weeks)
- Gene expression at the mRNA level of atrophy-associated genes (atrogenes)(Through completion of study, 16 weeks)
- Change in protein expression of anabolic signaling proteins(Through completion of study, 16 weeks)
- Change in protein expression of catabolic signaling proteins(Through completion of study, 16 weeks)
研究者
Michael Roberts
Professor
Auburn University