Tanzanian Endemic Optic Neuropathy (TEON): A pilot case control study of genetic, nutritional and environmental determinants.

niversity of St Andrews0 个研究点目标入组 60 人开始时间: 2020年4月29日最近更新: 2021年7月12日

适应症

试验速览

•Case group:
•1. Signed written consent from all participants, prior to undertaking any study procedures
•2. Aged 10-34 years
•3. The case definition of TEON, as per previous studies, is a bilateral optic neuropathy of subacute, progressive onset with best-corrected visual acuities of 6/9 or worse in both eyes, alongside an acquired colour vision deficiency, in the presence of temporal optic disc pallor (with OCT evidence of corresponding thinning) or optic disc hyperaemia
•4. Cases who meet the case definition and have been referred to the Eye Units in Dar es Salaam for further assessment
•Control group:
•1. Signed written consent from all participants prior to undertaking any study procedures
•2. Aged 10-34 years
•3. Participants who have had an ophthalmic history, examination and screening and satisfy the classification criteria for not being diagnosed with TEON
•4. Controls will, where possible, be first-degree relatives of a case group participant

•1. Cataract in either eye
•2. History of ocular trauma
•3. Diagnosis of another ocular pathology except refractive error
•4. Relative afferent pupillary defect
•5. Signs and symptoms suggestive of raised intracranial pressure
•6. Existing diagnosis of multiple sclerosis (or any other demyelinating condition)
•7. Untreated hypertension
•8. Unilateral disease
•9. Significant needle phobia
•10. Use of oral vitamin supplements
•11. Use of amiodarone, linezolid, ethambutol, isoniazid, tetracycline spp, oral chloramphenicol, methotrexate, lithium, metronidazole or omeprazole

发起方

niversity of St Andrews