Association Between Dietary Spermidine Intake and Mortality in the Population-based Bruneck Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 829
- 主要终点
- All-cause mortality
研究概览
简要总结
This study seeks to test the potential association between spermidine content in diet and mortality in humans.
详细描述
This prospective community-based cohort study includes 829 participants aged 45-84 years, 49.9% of which are male. Diet is assessed by repeated dietician-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. Nutrient intakes including spermidine are calculated using USDA standard databases. Clinical events (all-cause mortality and cause-specific mortality) are recorded from 1995 to 2015.
The primary endpoint of all-cause mortality is related to the exposure of long-term average spermidine intake by Cox proportional hazards models with time-varying covariates. Additional analyses employ the Fine and Gray proportional subdistribution hazards model and flexible Royston-Parmar spline-based models. Comprehensive sensitivity analyses are performed to guard against potential biases associated with nutritional epidemiology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Resident of Bruneck aged 40-79 years in 1990, age- and sex-stratified random sample.
排除标准
- 未提供
结局指标
主要结局
All-cause mortality
时间窗: 1995-2015
Death due to any cause
次要结局
- Cause-specific mortalities(1995-2015)
研究者
Stefan Kiechl
A.Univ.-Prof. Dr.
Medical University Innsbruck