Effect of Potato Fiber on Appetite and Fecal Fat Excretion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Subjective appetite sensations
研究概览
简要总结
Results have indicated that some dietary fibers increase fecal fat excretion and particularly viscous fibers suppress appetite sensation and reduce energy intake. Both these effects may contribute to body weight management.
Aim: The aim of the study is to investigate the potential of 3-weeks daily intake of potato pulp (FiberBind), rhamnogalacturonan I isolated potato fiber (RG-I) vs. a low-fiber control (placebo) on satiety and fecal fat excretion in healthy adults. Furthermore, a number of secondary endpoints are investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy Men
- •BMI between 18.5 and 27.0 kg/m2
- •Age 20-40 years
排除标准
- •Intake of potatoes with main meals more frequent than 4 times per week
- •Chronic diseases (known diabetes, cardiovascular disease, irritable bowels disease, colitis ulcerosa, crohn disease, or other chronic diseases which could affect the results of the present study)
- •Gluten allergy
- •Use of daily prescription medicine (mild analgesics are allowed)
- •Use of lipid-lowering agents (e.g. Becel, HUSK)
- •Use of food supplements of relevance to the study (such as pre- and probiotics)
- •Irregular intake of vitamin /mineral supplements (two weeks prior to and during the entire study period)
- •Elite athletes (>10 hours of strenuous physical activity per week)
- •Blood donation (<1 month before study commencement and during study period)
- •Participation in other clinical studies (<1 month before study commencement and during study period)
- •Inability (physically or psychologically) to comply with the procedures required by the protocol judged by the Investigator
研究组 & 干预措施
FiberBind
干预措施: FiberBind (Dietary Supplement)
RG-I fiber
干预措施: RG-I fiber (Dietary Supplement)
Placebo
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Subjective appetite sensations
时间窗: Assessed on 3-hour meal test on last day of the 21-day intervention periods
Assessed by visual analogue scales (VAS)
Fecal fat excretion
时间窗: Based on total feces collection the last 3 days of the 21-day intervention periods
次要结局
- Gastrointestinal symptoms (questionnaire)(on day 1, 7, 14 and 22 of the 21-day intervention periods)
- Blood pressure(up to 21-day intervention periods)
- Breath hydrogen(up to 21-day intervention periods)
- Gut microbiota(Measured in a fresh feces sample from day 19-21 of the intervention periods)
- Body weight(up to 21-day intervention periods)
- Ad libitum energy intake(Assessed 3 hours after intake of the test meal on last day of the 21-day intervention periods)
- Fecal energy excretion(Measured based on total feces collection the last 3 days of the 21-day intervention periods)
- Insulin and glucose(Measured before and after the 21-day intervention periods, and every 30 minutes during the 3-hour meal test on last day of the 21-week intervention periods)
- Gut permeability marker(Measured before and after the 21-day intervention periods)
- Gastric emptying rate (w. paracetamol)(Measured every 30 minutes during the 3-hour meal test on last day of the 21-day intervention periods)
- Blood lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides)(Measured before and after the 21-day intervention periods)
研究者
Anne Birgitte Raben
Professor
University of Copenhagen