Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- dynamic arterial elastance
研究概览
简要总结
Correction of arterial hypotension is essential for adequate cellular metabolism. maintaining MAP above a minimum level has been recommended in order to prevent further tissue hypoperfusion and organ dysfunction.Functional assessment of arterial load by dynamic arterial elastance (Eadyn), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent septic patients.
详细描述
After approval from the ethics and research committee of Faculty of Medicine, Cairo University, an informed consent will be obtained from each patient's next of kin. Arteial cathter will be inserted in radial artery and connected through an arterial line to invasive arterial blood pressure monitor. Electrical Cardiometry will be attached to patient through the placement of four skin sensors on the neck and left side of the thorax12. A set of hemodynamic measurements will be obtained at baseline and after infusing a fluid challenge (FC) of 150-250 ml normal saline over 5-10 minutes.Fluid-responders are patients with a SV increase ≥10% after fluid challenge (FC).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (more than 18 years).
- •Sepsis as a cause of admission.
排除标准
- •• Patients younger than 18 years of age.
- •Pregnant females.
- •Trauma as a cause of intensive care unit (ICU)admission.
- •Known medical history of vasodilator therapy.
- •Cardiac arrhythmias.
- •Any absolute contraindication for fluid administration such as congestive heart failure, pulmonary edema and/or fluid overload
结局指标
主要结局
dynamic arterial elastance
时间窗: 6 month
confirm the ability of non invasive (Eadyn) for predicting arterial pressure response to fluid challenge in septic patients
次要结局
未报告次要终点
研究者
soudy salah hammad
Anesthesia, ICU and pain management assistant lecturer ,Aswan University
Cairo University