Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy: A Randomized Double-blinded Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Postoperative morphine consumption (mg) in the first 24 hrs .
研究概览
简要总结
Renal cell carcinoma (RCC) accounts for 2-3% of all cancers and is a common malignancy of the genitourinary tract. Open nephrectomy, performed through midline, subcostal, or flank incisions, remains a standard treatment but often results in significant postoperative pain, leading to respiratory muscle dysfunction, increased pulmonary complications, and prolonged hospital stays.
Acute surgical pain arises from inflammatory responses, activation of spinal pain pathways, and muscle spasms. While postoperative pain typically improves during recovery, some patients develop chronic postsurgical pain (CPSP), lasting at least two months postoperatively.
Opioids and epidural analgesia are commonly used for pain control, but their side effects and invasiveness necessitate safer, effective alternatives. Ultrasound (US)-guided peripheral nerve and field blocks have become integral to multimodal analgesia. One such technique, the **external oblique intercostal plane block (EOIPB)**, was introduced as a modification of fascial plane blocks, targeting anterior and lateral cutaneous nerves (T6-T10). EOIPB offers advantages over quadratus lumborum block (QLB) and erector spinae plane block (ESPB) by being performed in the supine position and providing superior midline analgesia compared to serratus intercostal plane block (SIPB).
Similarly, the transversus abdominis plane (TAP) block, particularly the posterior approach, delivers analgesia from T7 to T12 by anesthetizing anterior and lateral cutaneous nerve branches. While case series suggest EOIPB may be effective for post-nephrectomy pain, comparative studies between EOIPB and posterior TAP block in open nephrectomy:
Aim of the Study:
To evaluate the postoperative analgesic effects of posterior transversus abdominis plane (TAP) block and external oblique intercostal plane block (EOIPB) in patients undergoing open nephrectomy under general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients whom diagnosed as having renal carcinoma and scheduled for open nephrectomy under general anesthesia.
- •ASA class II- III.
- •Age ≥ 18 and ≤ 70 years.
- •Body mass index (BMI) less than 40kg/m2.
排除标准
- •Patient refusal.
- •Hepatic and renal insufficiency.
- •Unstable cardiovascular or pulmonary disease.
- •History of psychiatric and cognitive disorders.
- •Patients with known sensitivity or contraindications to the drug used.
- •Patients on regular opioid consumption.
研究组 & 干预措施
Posterior TAP - Group
干预措施: US-guided external oblique intercostal plane block (EOIPB) (Procedure)
EOIPB-Group
干预措施: US-guided external oblique intercostal plane block (EOIPB) (Procedure)
结局指标
主要结局
Postoperative morphine consumption (mg) in the first 24 hrs .
时间窗: Time elapsed from the end of the block procedure till the end of the 24 hours postoperatively
次要结局
未报告次要终点