The Neural Mechanisms of Anesthesia and Human Consciousness - The Neural Mechanisms of Anesthesia and Human Consciousness

Harry Scheinin0 个研究点开始时间: 2013年6月10日最近更新: 2016年2月8日

适应症

试验速览

暂无简介。

•Healthy male volunteers will be considered eligible for the study.
•The subjects must meet all of the following criteria:
•2. Age 20–30 years
•3. Good general health i.e. American Society of Anesthesiologists (ASA) physical status I
•4. Fluent in Finnish language
•5. Right handedness
•6. Written informed consent
•7. Good sleep quality
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•The subject must be excluded if any of the following criteria are met:
•1. Chronic medication
•2. History of alcohol and/or drug abuse
•3. Strong susceptibility for allergic reactions
•4. Serious nausea in connection with previous anesthesia
•5. Strong susceptibility for nausea
•6. Any use of drugs or alcohol during the 48 hours preceding anesthesia
•7. Use of caffeine products 10–12 hours prior the study, 24 hours before sleep studies
•8. Smoking
•9. Clinically significant previous cardiac arrhythmia / cardiac conduction impairment
•10. Clinically significant abnormality in prestudy laboratory tests
•11. Positive result in the drug screening test
•12. Blood donation within 90 days prior to the study
•13. Participation in any medical study with an experimental drug or device during the preceding 60
•14. The study subject has undergone a prior PET or SPECT study
•15. Any contraindication to magnetic resonance imaging (MRI)
•16. Hearing impairment
•17. Detected unsuitability based on initial electrophysiological measurements (Parts 2–5)
•18. Detected unsuitability based on MRI scanning results (Parts 3–6)
•19. Sleep disorder or severe sleep problem

发起方

Harry Scheinin