Combined Use of Multiple Biomarkers With Stress Testing to Detect Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 850
- 试验地点
- 1
- 主要终点
- Diagnosis of coronary artery disease
研究概览
简要总结
Main aim of the COMBAT-CAD-Study is to clarify, if the combination of stress testing with biomarkers improves the diagnostic accuracy.
Hypothesis of our study is that diagnosis of CAD can be improved by adding biomarkers to solely stress testing for the workup of patients with suspected CAD or progress of already known CAD.
详细描述
The COMBAT-CAD Study is an observational study with the aim to improve the diagnostic accuracy by a combination of stress testing with sensitive and specific biomarkers in detecting coronary artery disease or its progress. The main subjects are all patients with CAD or suspicion of CAD sent to the University Heart Center Hamburg. In these patients, ECG, laboratory examination, symptoms or transthoracic echocardiography in rest could not rule out CAD or progress of known CAD. The hypothesis of the study is that detection of CAD can be improved by adding biomarkers to stress testing for the diagnostic workup of patients with suspected CAD or progress of already known CAD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Every patient referred to coronary angiography, or diagnostic work-up with suspicion of CAD or progress of CAD (in case of CABG patients or already treated with PCI)
排除标准
- •Insufficient knowledge of the German language (able to understand and write the German language)
- •Physical or psychological incapability to take part in the investigation
- •Persons with no sufficient language ability in German to understand the provided study information material.
结局指标
主要结局
Diagnosis of coronary artery disease
时间窗: Within the initial diagnostic evaluation process (maximum within 30 days)
The diagnosis of coronary artery disease through stress testing alone and combined with cardiac biomarkers.
次要结局
未报告次要终点