To compare the effect of palonosetron and ondansetron in preventing post operative nausea vomiting in patient undergoing living donor renal transplantation : a randomized double blind observational study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- To compare the effects of polonosetron and ondensteronin preventing post operative nausea and vomiting using PONV score wengritzky Rt.al
研究概览
简要总结
Post operative nausea and vomiting is a common complaint in the post operative period , in patients with end stage renal disease they have delayed gastric emptying due to urenmic Gastro patchy and concomitant diabetes increases changes of nausea and vomiting in post operative period. Ondensetron is a short acting antiemetic , which has limited duration of action. Palonosetron is a long acting antiemetic which not only decreases early onset PONV but also decreases nausea and vomiting 48-72 hrs after transplantation. We aim to compare the efficacy of these two agents by using the PONV intensity score.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Renal transplant recipients.
排除标准
- •History of motion sickness History of chronic anti emetic medications Known smokers History of allergy to ondensetron and polonosetron.
结局指标
主要结局
To compare the effects of polonosetron and ondensteronin preventing post operative nausea and vomiting using PONV score wengritzky Rt.al
时间窗: To compare the effects of polonosetron and ondensteronin preventing post operative nausea and vomiting using PONV score wengritzky Rt.al at 0,1hr, 6hr, 12hr,24hr and 72 hrs after surgery
次要结局
- Not applicable(Not applicable)