Stress system dynamics in childhood trauma-related depression - REACT

Amsterdam UMC0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•General inclusion criteria:
•- Mastery of Dutch language
•- Age of >= 18 years
•- Willingness and ability to give written informed consent
•- Normal or corrected-to-normal vision
•Additional inclusion criteria for the patient groups (i.e., MDD+CT and MDD-CT):
•- Moderate to severe depression
•- Score >= 26 on the Inventory of Depressive Symptoms-Self Report
•(IDS-SR) (Rush et al., 2000)
•- DSM-5 diagnosis of major depression disorder (MDD), confirmed with clinical
•interview (MINI (Sheehan et al., 1997))
•Additional inclusion criteria for the MDD+CT group:
•- Moderate to severe childhood trauma (CT) before the age of 18
•- Score above validated cut-off for moderate to severe CT using the
•Childhood Trauma Questionnaire (CTQ) (Bernstein et al., 1994):

•General exclusion criteria:
•- Speech impairments
•- Other lifetime severe psychiatric comorbidity (bipolar disorder, psychotic
•disorder) or current alcohol/drug dependence
•- Primary diagnosis of post-traumatic stress disorder (PTSD) or Acute Stress
•Disorder (ASD)
•- Lifetime diagnosis of borderline personality disorder (BPD)
•- Any acute somatic or acute endocrine disease (e.g., acute asthma)
•- Taking any medication known to influence endocrine systems
•- Chronic benzodiazepine use (and sporadic use on the days of the lab visits)
•- Neurological disorder
•- Known contraindications for MRI investigations, such as the presence of metal
•objects (e.g., pacemaker, arteriovenous clips) or severe claustrophobia.
•Additional exclusion criteria for healthy controls and MDD-CT patients:
•- Moderate to severe childhood trauma (CT) before the age of 18
•- Score above validated cut-off for moderate to severe CT using CTQ
•(see cutoff scores
•Additional exclusion criteria for healthy controls:
•- Past or present psychiatric condition.

发起方

Amsterdam UMC